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When B cells express the IgD, B cells up-regulate the chemokine receptor CXCR5 [16], and recirculating naive B cells overexpress CXCR5 in response to the chemokine CXCL13, which encourages their migration towards B cell follicles [17]

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That timeline mirrors the decline in skin elasticity, wound closure speed, and overall tissue repair capacity that aging brings